Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines

Detection of specific sequences among DNA fragments separated by gel electrophoresis

E.M. Southern · Journal of Molecular Biology · 1975 · 32.8K citations

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Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

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A procedure for the isolation of deoxyribonucleic acid from micro-organisms

Julius Marmur · Journal of Molecular Biology · 1961 · 11.6K citations

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Genetic Alterations during Colorectal-Tumor Development

Bert Vogelstein, Eric R. Fearon, Stanley R. Hamilton et al. · New England Journal of Medicine · 1988 · 6.8K citations

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Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

Helmut Zarbl, Saraswati Sukumar, Anne V. Arthur et al. · Nature · 1985 · 826 citations

Medicine, Genetics, Molecular Biology +14