Greatly Improved Blood Compatibility by Microscopic Multiscale Design of Surface Architectures

Abstract

A multiscale architecture with interlaced submicrometer ridges and nanoprotrusions is built on a polydimethylsiloxane (PDMS) surface by a combination of self-assembly, soft lithography, and physical treatment (see picture). The multiscale structure reduces activated-platelet adhesion under flow conditions, which is significant for the development of blood-contacting materials. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.