Oxidative DNA damage as a marker of aging in WI-38 human fibroblasts

A simple technique for quantitation of low levels of DNA damage in individual cells

Narendra P. Singh, Michael T. McCoy, Raymond R. Tice et al. · Experimental Cell Research · 1988 · 10.8K citations · Full text

Pharmacy, Cell Biology, Molecular Biology +10

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.4K citations · Full text

Education, Cell Biology, Molecular Biology +15

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

Arne Klungland, Ian Rosewell, Stephan Hollenbach et al. · Proceedings of the National Academy of Sciences · 1999 · 798 citations

Life Sciences, Genetics, Molecular Biology +17

Does oxidative damage to DNA increase with age?

Michelle L. Hamilton, Holly Van Remmen, Jessica A. Drake et al. · Proceedings of the National Academy of Sciences · 2001 · 761 citations · Full text

Life Sciences, Biochemistry, Genetics +15

Oxidative DNA damage and senescence of human diploid fibroblast cells.

Qian Chen, Ann Fischer, Jeff D. Reagan et al. · Proceedings of the National Academy of Sciences · 1995 · 711 citations

Life Sciences, Biochemistry, Cell Biology +17