Chemical Communications · 2014 · 113 citations · 12 references
PharmacyMolecular PharmaceuticsPharmaceuticsDrug DeliveryNanoparticle Drug DeliveryTargeted Drug DeliveryCancer Drug DeliveryCancer NanomedicineNanocarriers For TherapeuticsNanomaterials For Drug DeliveryTargeted Cancer TherapyTargeted TherapyAnticancer Drug LoadingApoptosis TargetingMicellesNanoparticle-based ChemotherapyPolymeric MicellesStimuli-responsive MicellesTargeted Therapy-induced ApoptosisTumor-targeted Drug Delivery
Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were prepared to selectively eliminate cancer cells. The micelles were able to enhance cancer cell uptake via the receptor-mediated endocytosis and respond to the stimulus of cancer cell excessive secreted protease MMP-2 to release the anticancer drug and induce apoptosis of cancer cells in a targeted manner.
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