Concepedia

In Vivo Evaluation of Drug-Drug Interaction via Mechanism-Based Inhibition by Macrolide Antibiotics in Cynomolgus Monkeys

Akihito Ogasawara, Isao Negishi, Kazumasa Kozakai, Toshiyuki Kume

Drug Metabolism and Disposition · 2009 · 15 citations · 34 references

DOI

Concepts

References

34

Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan · Drug Metabolism and Disposition · 2006 · 456 citations

, , +17

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin*

Jack Gorski, D. I. Jones, B HAEHNERDANIELS et al. · Clinical Pharmacology & Therapeutics · 1998 · 411 citations

, , +14

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily

Jack Gorski, Stephen D. Hall, D. I. Jones et al. · Biochemical Pharmacology · 1994 · 397 citations

, , +12

A potentially hazardous interaction between erythromycin and midazolam

Klaus T. Olkkola, Kari Aranko, Harri Luurila et al. · Clinical Pharmacology & Therapeutics · 1993 · 354 citations

, , +13

An In Vitro Model for Predicting In Vivo Inhibition of Cytochrome P450 3A4 by Metabolic Intermediate Complex Formation

David R. Jones, Stephen D. Hall · Drug Metabolism and Disposition · 2000 · 294 citations

, , +17