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Differentiation of Human IgM Subclasses by the Ability to Interact with a Factor Resembling the First Component of Complement
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1969
Year
Human Igm ProteinsGeneticsImmunologyMolecular GeneticsProtein GeneticsImmune-related Gene PolymorphismImmunogeneticsTranscriptional RegulationHuman Igm SubclassesHuman SerumMolecular DiagnosticsGene ExpressionComplement SystemDevelopmental BiologyChromatin StructureNatural SciencesImmunoglobulin EAbstract TwoMedical GeneticsMedicineFirst ComponentCell Development
Abstract Two groups of human IgM proteins are described. One group interacts with a heat-labile component of rabbit or human serum which has characteristics similar to C′1q. The second group fails to interact with this factor. This grouping is not related to κ or λ chains or to previously described differences in human IgM molecules. Such a division may provide a tool for the identification of µ chain genetic markers.