Mixed endothelin receptor antagonist, SB209670, decreases portal pressure in biliary cirrhotic rats in vivo by reducing portal venous system resistance

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

Gilberto De Nucci, Ranjeny Thomas, Pedro D’Orléans-Juste et al. · Proceedings of the National Academy of Sciences · 1988 · 1.4K citations · Full text

Medicine, Pharmacology, Physiology +12

Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788.

Kiyofumi Ishikawa, M. Ihara, Kazuhito Noguchi et al. · Proceedings of the National Academy of Sciences · 1994 · 574 citations

Medicine, Pharmacology, Physiology +12

Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension

Julio Vorobioff, James E. Bredfeldt, R. J. Groszmann · American Journal of Physiology-Gastrointestinal and Liver Physiology · 1983 · 438 citations

Medicine, Physiology, Surgery +16

Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells

Massimo Pinzani, Stefano Milani, Raffaella De Franco et al. · Gastroenterology · 1996 · 402 citations

Life Sciences, Biochemistry, Cell Biology +17

Endothelin Induced Contractility of Stellate Cells From Normal and Cirrhotic Rat Liver: Implications for Regulation of Portal Pressure and Resistance

Don C. Rockey, Richard A. Weisiger · Hepatology · 1996 · 386 citations · Full text

Life Sciences, Cell Biology, Physiology +17