Concepedia

The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas

Eva Hernando, Elizabeth Charytonowicz, Mária Dudás, Sílvia Menéndez, Igor Matushansky, Joslyn Mills, Nicholas D. Socci, Nille Behrendt, Li Ma, Robert G. Maki,

Nature Medicine · 2007 · 286 citations · 25 references

DOI

Concepts

References

25

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

Dos D. Sarbassov, David A. Guertin, Siraj M. Ali et al. · Science · 2005 · 6.2K citations

, , +17

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations

, , +14

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Zhenbang Chen, Lloyd C. Trotman, David R. Shaffer et al. · Nature · 2005 · 2K citations · Full text

, , +16

Phosphorylation and Functional Inactivation of TSC2 by Erk

Li Ma, Zhenbang Chen, Hediye Erdjument‐Bromage et al. · Cell · 2005 · 1.3K citations · Full text

, , +8

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

Pradip K. Majumder, Phillip G. Febbo, Rachel Bikoff et al. · Nature Medicine · 2004 · 956 citations

, , +15