Fas Signaling in Thyroid Carcinomas Is Diverted from Apoptosis to Proliferation

Abstract

In thyroid carcinomas, the proteolytic cleavage and activation of caspase-8 depends on the balance between expression levels for procaspase-8 and FLIP and correlates with favorable clinical prognosis. Fas may actually stimulate proliferation and confer a survival advantage to thyroid cancer cells.