Nuclear factor ?B/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1?-stimulated synovial fibroblasts

Abstract

These studies demonstrate, for the first time, a role for NF-kappaB in the induction of MMP-1, and suggest a mechanism of NF-kappaB-mediated cartilage degradation in rheumatoid arthritis.