A Functional Single-Nucleotide Polymorphism in the <i>TRPC6</i> Gene Promoter Associated With Idiopathic Pulmonary Arterial Hypertension

Abstract

These results suggest that the -254(C-->G) SNP may predispose individuals to an increased risk of IPAH by linking abnormal TRPC6 transcription to nuclear factor-kappaB, an inflammatory transcription factor.