STX140 Is Efficacious <i>In vitro</i> and <i>In vivo</i> in Taxane-Resistant Breast Carcinoma Cells

Abstract

STX140 shows excellent efficacy in both MCF-7(WT) and MCF-7(DOX) breast cancer xenograft models, in contrast to Taxol and 2-MeOE2. The clinical potential of STX140 was further highlighted by the efficacy seen in xenografts recently derived from patients who had failed on taxane therapy.