Total syntheses of phleigchrome, calphostin A, and calphostin D. Unusual stereoselective and stereospecific reactions in the synthesis of perylenequinones

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

Eiji Kobayashi, Hirofumi Nakano, Makoto Morimoto et al. · Biochemical and Biophysical Research Communications · 1989 · 1.1K citations

Life Sciences, Biochemistry, Medicinal Chemistry +9

Nickel-Phosphine Complex-Catalyzed Grignard Coupling. I. Cross-Coupling of Alkyl, Aryl, and Alkenyl Grignard Reagents with Aryl and Alkenyl Halides: General Scope and Limitations

Kohei Tamao, Koji Sumitani, Yoshihisa Kiso et al. · Bulletin of the Chemical Society of Japan · 1976 · 589 citations · Full text

Natural Sciences, Chemistry, Catalysis +16

Asymmetric synthesis catalyzed by chiral ferrocenylphosphine-transition-metal complexes. 6. Practical asymmetric synthesis of 1,1'-binaphthyls via asymmetric cross-coupling with a chiral [(alkoxyalkyl)ferrocenyl]monophosphine/nickel catalyst

Tamio Hayashi, Keiichi Hayashizaki, Takao Kiyoi et al. · Journal of the American Chemical Society · 1988 · 312 citations

Natural Sciences, Chemistry, Catalysis +10

Host-guest complexation. 16. Synthesis and cation binding characteristics of macrocyclic polyethers containing convergent methoxyaryl groups

Karl E. Koenig, George M. Lein, Peter Stückler et al. · Journal of the American Chemical Society · 1979 · 204 citations

Natural Sciences, Chemistry, Organic Chemistry +10

Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities.

Eiji Kobayashi, Katsuhiko Ando, Hirofumi Nakano et al. · The Journal of Antibiotics · 1989 · 148 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +6