Active Apical Secretory Efflux of the HIV Protease Inhibitors Saquinavir and Ritonavir in Caco-2 Cell Monolayers

Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) Cells

Per Artursson · Journal of Pharmaceutical Sciences · 1990 · 836 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

Dale J. Kempf, Kennan C. Marsh, Jon F. Denissen et al. · Proceedings of the National Academy of Sciences · 1995 · 556 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators

Janice Hunter, Mark A. Jepson, T Tsuruo et al. · Journal of Biological Chemistry · 1993 · 367 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

Gondi Kumar, A. David Rodrigues, Alex Buko et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 352 citations

Medicine, Pharmacokinetics, Pharmacology +17

The Effect of High-Dose Saquinavir on Viral Load and CD4+ T-Cell Counts in HIV-Infected Patients

Jonathan Schapiro · Annals of Internal Medicine · 1996 · 299 citations

Pharmacy, Infectious Diseases, Pharmacotherapy +17