Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori et al. · Nature · 1998 · 5.2K citations

Life Sciences, Genetics, Molecular Genetics +10

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Derek P. Narendra, Atsushi Tanaka, Der‐Fen Suen et al. · The Journal of Cell Biology · 2008 · 4K citations · Full text

Life Sciences, Cell Biology, Neuroscience +17

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

Enza Maria Valente, Patrick M. Abou‐Sleiman, Viviana Caputo et al. · Science · 2004 · 3.5K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Gilad Twig, Álvaro A. Elorza, Anthony Molina et al. · The EMBO Journal · 2008 · 3.1K citations · Full text

Life Sciences, Biology, Cell Biology +12

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Derek P. Narendra, Seok Min Jin, Atsushi Tanaka et al. · PLoS Biology · 2010 · 2.9K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17