Concepedia

2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2

Li Ma, Guangxin Li, Huaqiang Zhu, Xuesong Dong, Dali Zhao, Xian Jiang, Jie Li, Haiquan Qiao, Shaobin Ni, Xueying Sun

Cancer Letters · 2014 · 90 citations · 36 references

Concepts

MedicineOncologyPharmacologyCancer PharmacologyMolecular OncologyTumor MicroenvironmentHepatocellular CarcinomaHepatocellular Carcinoma PharmacotherapyHormonal Cancer TherapyHormonal TherapyHypoxia AdaptationLiver CancerHepatocellular Carcinoma TreatmentHypoxia ModulationHypoxia-induced SignalingSorafenib TherapyTumor Microenvironment Hypoxia

References

36

Global cancer statistics

Ahmedin Jemal, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text

Medicine, Oncology, Cancer Epidemiology +15

Sorafenib in Advanced Hepatocellular Carcinoma

Josep M. Llovet, Sergio Ricci, Vincenzo Mazzaferro et al. · New England Journal of Medicine · 2008 · 13K citations · Full text

Medicine, Oncology, Pharmacology +12

Management of Hepatocellular Carcinoma: An Update Δσ

Jordi Bruix, Morris Sherman · Hepatology · 2011 · 8.1K citations · Full text

Medicine, Internal Medicine, Oncology +14

Sorafenib in Advanced Hepatocellular Carcinoma

재연 정 · 2008 · 5.6K citations

Medicine, Oncology, Pharmacology +12

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16