Concepedia

Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications

M.C. Van Zandt, E. Sibley, Erin E. McCann, Kerry J. Combs, Brenda R. Flam, Diane R. Sawicki, Al Sabetta, Anne L. Carrington, Janet Sredy, Eduardo Howard,

Bioorganic & Medicinal Chemistry · 2004 · 48 citations · 38 references

Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoverySynthetic Medicinal ChemistryDiabetes MellitusDiabetes Mellitus BiochemistryDiabetes PharmacotherapyEnzyme InhibitionLead Compound DesignLigand-based DesignAldo-keto Reductase CatalysisAldo-keto ReductasesAldose Reductase TargetsAntidiabetic ActivityAntidiabetic Drug TherapyDiabetic Complications

References

38

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

New England Journal of Medicine · 1993 · 24.7K citations · Full text

Medicine, Endocrinology, Internal Medicine +14

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

The Lancet · 1998 · 20.1K citations

Medicine, Endocrinology, Pharmacotherapy +13

Improved methods for building protein models in electron density maps and the location of errors in these models

T. Alwyn Jones, Jin-yu Zou, Sandra W. Cowan et al. · Acta Crystallographica Section A Foundations of Crystallography · 1991 · 12.7K citations

Life Sciences, Biochemistry, Biomolecular Modeling +16

Methods of enzymatic analysis

Food and Cosmetics Toxicology · 1966 · 4.3K citations

Life Sciences, Biochemistry, Analytical Chemistry +11

Isolation and Properties of Lens Aldose Reductase

Selma Hayman, Jin H. Kinoshita · Journal of Biological Chemistry · 1965 · 560 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9