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Optimization of Taxane Binding to Microtubules: Binding Affinity Dissection and Incremental Construction of a High-Affinity Analog of Paclitaxel

Taxane BindingMedicinal ChemistryHigh-affinity AnalogMedicineNatural SciencesPolymer-drug ConjugateMolecular BiologyBinding Affinity DissectionCytoskeletonBiomolecular InteractionMolecular DockingBiophysicsDrug DiscoveryBio-orthogonal Chemistry