Concepedia

Optimization of Taxane Binding to Microtubules: Binding Affinity Dissection and Incremental Construction of a High-Affinity Analog of Paclitaxel

Ruth Matesanz, Isabel Barasoaı́n, Chun‐Gang Yang, Lei Wang, Xuan Li, Concepción de Inés, Claire Coderch, Federico Gago, Jesús Jiménez‐Barbero, José M. Andreu,

Chemistry & Biology · 2008 · 78 citations · 34 references

DOI

Concepts

References

34

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

Wendy D. Cornell, Piotr Cieplak, Christopher I. Bayly et al. · Journal of the American Chemical Society · 1995 · 13.1K citations

, , +17

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

Garrett M. Morris, David S. Goodsell, Robert S. Halliday et al. · Journal of Computational Chemistry · 1998 · 10.8K citations

, , +17

H++: a server for estimating pKas and adding missing hydrogens to macromolecules

John Gordon, Joseph B. Myers, T. Folta et al. · Nucleic Acids Research · 2005 · 1.8K citations · Full text

, , +17

Refined structure of αβ-tubulin at 3.5 Å resolution 1 1Edited by I. A. Wilson

Jan Löwe, Huilin Li, Kenneth H. Downing et al. · Journal of Molecular Biology · 2001 · 1.2K citations

, , +10

Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: Reversibility, ligand stoichiometry, and competition

José M. Andreu · Biochemistry · 1993 · 416 citations

, , +9