Investigations of the genomic region that contains the <i>clf1</i> mutation, a causal gene in multifactorial cleft lip and palate in mice

Abstract

The clf1 mutation is a genomic alteration present in A/WySn and absent in the ancestral chromosomal segment in CBA/J. The IAP retrotransposon insertion near Wnt9b in A/WySn fits this criterion; we predict that interference with Wnt9b function by this IAP is the clf1 mutation.