Concepedia

Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis

Heather R. Pelzel, Cassandra L. Schlamp, Robert W. Nickells

BMC Neuroscience · 2010 · 147 citations · 47 references

DOIFull text

Open access

Abstract

These data indicate that histone deacetylation plays a central role in transcriptional dysregulation in dying RGCs. The data also suggests that HDAC3, in particular, may feature heavily in apoptotic gene silencing.

References

47

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

Joan S. Steffan, László Bodai, Judit Pallos et al. · Nature · 2001 · 1.2K citations

, , +6

Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses

Eric M. Blalock, James W. Geddes, Kuey Chu Chen et al. · Proceedings of the National Academy of Sciences · 2004 · 1K citations · Full text

Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis.

Harry A. Quigley, Robert W. Nickells, Lisa A. Kerrigan et al. · PubMed · 1995 · 931 citations

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

Emma Hockly, Victoria M. Richon, Benjamin Woodman et al. · Proceedings of the National Academy of Sciences · 2003 · 836 citations · Full text

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

Nagma Khan, Michael Jeffers, Sampath Kumar et al. · Biochemical Journal · 2007 · 707 citations · Full text

, , +20