Lymphotoxin pathway directs thymic Aire expression

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

Mark S. Anderson, Emily S. Venanzi, Ludger Klein et al. · Science · 2002 · 2.4K citations

Immunology, Immune Regulation, Antigen Processing +18

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

Johanna Aaltonen, Petra Björses, Jaakko Perheentupa et al. · Nature Genetics · 1997 · 1.2K citations

Autoimmune Disease, Novel Gene, Autoantibody Production +11

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

Jens Derbinski, Antje Schulte, Bruno Kyewski et al. · Nature Immunology · 2001 · 1K citations

Promiscuous Gene Expression, Lineage Plasticity, Developmental Biology +11

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

Emmanuel Dejardin, Nathalie Droin, Mireille Delhase et al. · Immunity · 2002 · 910 citations · Full text

Inflammation, Transcriptional Regulation, Signal Transduction +11

Aire regulates negative selection of organ-specific T cells

Adrian Liston, Sylvie Lesage, Judith Wilson et al. · Nature Immunology · 2003 · 788 citations

Cell Signaling, T-regulatory Cell, Immunology +6