Concepedia

Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing

Roman K. Thomas, Elizabeth Nickerson, Jan Fredrik Simons, Pasi A. Jänne, Torstein Tengs, Yuki Yuza, Levi A. Garraway, Thomas LaFramboise, Jeffrey C. Lee, Kinjal Shah,

Nature Medicine · 2006 · 391 citations · 16 references

DOI

Concepts

References

16

DNA sequencing with chain-terminating inhibitors

Frederick Sanger, S. Nicklen, Alan Coulson · Proceedings of the National Academy of Sciences · 1977 · 69.3K citations · Full text

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Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella et al. · New England Journal of Medicine · 2004 · 11.5K citations

, , +16

<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

J. Guillermo Paez, Pasi A. Jänne, Jeffrey C. Lee et al. · Science · 2004 · 9.4K citations

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Genome sequencing in microfabricated high-density picolitre reactors

Marcel Margulies, William E. Altman, Said Attiya et al. · Nature · 2005 · 7.7K citations · Full text

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EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

William Pao, Vincent A. Miller, Maureen F. Zakowski et al. · Proceedings of the National Academy of Sciences · 2004 · 4.3K citations · Full text

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