Phosphorylation/Cytoplasmic Localization of p21Cip1/WAF1 Is Associated with HER2/<b> <i>neu</i> </b> Overexpression and Provides a Novel Combination Predictor for Poor Prognosis in Breast Cancer Patients

Abstract

The present study, in addition to supporting the mechanisms of p21 regulation derived from laboratory investigation, demonstrates the prognostic importance of phospho-p21 (T145) for the first time and also provides a novel combination of p21 and HER2/neu for better stratification of patients' survival than any single clinicopathological or biological marker that may play important diagnostic and therapeutic roles for breast cancer patients.