A 13C Isotope Labeling Strategy Reveals the Influence of Insulin Signaling on Lipogenesis in C. elegans

A C. elegans mutant that lives twice as long as wild type

Cynthia Kenyon, Jean Chang, Erin Gensch et al. · Nature · 1993 · 3.4K citations

Life Sciences, Biology, Genetics +6

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Coleen T. Murphy, Steven A. McCarroll, Cornelia I. Bargmann et al. · Nature · 2003 · 2.3K citations

Education, Genetics, Molecular Genetics +11

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Jens C. Brüning, Dinesh Gautam, Deborah J. Burks et al. · Science · 2000 · 2.2K citations

Life Sciences, Neuroscience, Physiology +17

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Martin Holzenberger, Joëlle Dupont, Bertrand Ducos et al. · Nature · 2002 · 2.1K citations · Full text

Education, Genetics, Molecular Genetics +12

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

Scott Ogg, Suzanne Paradis, S Gottlieb et al. · Nature · 1997 · 2K citations

Life Sciences, Genetics, Molecular Biology +13