Concepedia

Convergent Chemical Synthesis of Histone H2B Protein for the Site‐Specific Ubiquitination at Lys34

Peter Siman, Subramanian Vedhanarayanan Karthikeyan, Miroslav Nikolov, Wolfgang Fischle, Ashraf Brik

Angewandte Chemie International Edition · 2013 · 136 citations · 31 references

DOI

Concepts

Abstract

As You Like It: The convergent chemical synthesis of the histone H2B protein was achieved. This approach enabled the attachment of ubiquitin at Lys34 (see picture) and should make it possible to synthesize H2B with any other posttranslational modification in demand.

References

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