Specific Mutations in <i>KRAS</i> Codons 12 and 13, and Patient Prognosis in 1075 <i>BRAF</i> Wild-Type Colorectal Cancers

Abstract

KRAS codon 12 mutations (in particular, c.35G>T), but not codon 13 mutations, are associated with inferior survival in BRAF wild-type colorectal cancer. Our data highlight the importance of accurate molecular characterization in colorectal cancer.