Codon 12 Mutations is a specific type of point mutation occurring in the RAS family oncogenes wherein a single nucleotide substitution at the twelfth codon of the gene leads to a constitutively active RAS protein, thereby promoting oncogenic signal transduction and tumorigenesis.
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A Comprehensive Survey of Ras Mutations in Cancer
Ian A. Prior, Paul D. Lewis, Carla Mattos · Cancer Research · 2012 · 2.1K citations · Full text
Acquired Resistance to KRAS <sup>G12C</sup> Inhibition in Cancer
New England Journal of Medicine · 2021 · 1.2K citations · Full text
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National Cancer Institute
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National Cancer Research Institute
London, United Kingdom
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Johns Hopkins University
Baltimore, United States
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Kanazawa University
Kanazawa, Japan
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75 publications
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Hokkaido University
Sapporo, Japan
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University of Amsterdam
Amsterdam, The Netherlands
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Institute of Cancer Research
London, United Kingdom
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Harvard University
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