Antinociception, Tolerance, and Physical Dependence Comparison Between Morphine and Tramadol

Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic.

Robert B. Raffa, Elmar Friderichs, Wolfgang Reimann et al. · Journal of Pharmacology and Experimental Therapeutics · 1992 · 1.2K citations

Medicine, Pharmacology, Pharmacotherapy +17

Tramadol: pain relief by an opioid without depression of respiration

M D Vickers, D. O’Flaherty, S. M. SZEKELY et al. · Anaesthesia · 1992 · 439 citations · Full text

Medicine, Anesthesiology, Pharmacology +14

Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids.

H.‐H. Hennies, Elmar Friderichs, Johannes Schneider · PubMed · 1988 · 303 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Interaction of the central analgesic, tramadol, with the uptake and release of 5‐hydroxytryptamine in the rat brain <i>in vitro</i>

Bernd Driessen, Wolfgang Reimann · British Journal of Pharmacology · 1992 · 243 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Abuse potential and pharmacological comparison of tramadol and morphine

Kenzie L. Preston, Donald R. Jasinski, Margaret Testa · Drug and Alcohol Dependence · 1991 · 241 citations

Medicine, Pharmacology, Pharmacotherapy +12