Concepedia

High-Affinity Binding of [3H]Cimetidine to a Heme-Containing Protein in Rat Brain

Rebecca Stadel, Jun Yang, Julia W. Nalwalk, James G. Phillips, Lindsay B. Hough

Drug Metabolism and Disposition · 2007 · 11 citations · 42 references

Open access

Concepts

MedicineMedicinal ChemistryPharmacologyBiochemical PharmacologyMolecular PharmacologyPharmacodynamicsCytochrome P450 EnzymesCytochrome P450 InteractionsDrug-receptor InteractionsLigand BindingCyp450-mediated InteractionsCytochrome P450 Enzyme ActivityCytochrome P450 Enzyme InhibitionCytochrome P450 InhibitionCytochrome P450 Ligand BindingCytochrome P450 SelectivityCytochrome P450 Structure-function RelationshipsCytochrome P450 Substrate Specificity

References

42

Determination and characterization of a cannabinoid receptor in rat brain.

William A. Devane, F A Dysarz, M R Johnson et al. · Molecular Pharmacology · 1988 · 2.4K citations

Medicine, Neuroscience, Pharmacology +12

The Cytochrome P450 Homepage

David R. Nelson · Human Genomics · 2009 · 1K citations · Full text

Life Sciences, Bioinformatics, Genetics +11

Reactions and significance of cytochrome P-450 enzymes

F. Peter Guengerich · Journal of Biological Chemistry · 1991 · 603 citations · Full text

Life Sciences, Biochemistry, Enzyme Mechanism +16

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

Kim Brøsen, Erik Skjelbo, Birgitte Buur Rasmussen et al. · Biochemical Pharmacology · 1993 · 372 citations

Medicine, Pharmacokinetics, Pharmacology +13

Characterization of the In Vitro Biotransformation of the HIV-1 Reverse Transcriptase Inhibitor Nevirapine by Human Hepatic Cytochromes P-450

David A. Erickson, Gary Mather, W. Trager et al. · Drug Metabolism and Disposition · 1999 · 276 citations

Medicine, Pharmacokinetics, Pharmacology +17