Modulation of steady‐state kinetics of digoxin by haplotypes of the P‐glycoprotein <i>MDR1</i> gene - Concepedia

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Modulation of steady‐state kinetics of digoxin by haplotypes of the P‐glycoprotein <i>MDR1</i> gene

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References

2002

Year

Andreas Johne, Karla Köpke, Thomas Gerloff, Ingrid Mai, Stephan Rietbrock, Christian Meisel, Sven Hoffmeyer, Reinhold Kerb, Martin F. Fromm, Ulrich Brinkmann,

Clinical Pharmacology & Therapeutics

Abstract

Haplotype 12 codes for high values of AUC(0-4) and C(max) of orally administered digoxin. Analysis of MDR1 haplotypes is superior to unphased SNP analysis to predict MDR1 phenotype.