Complex Drugs and Biologics: Scientific and Regulatory Challenges for Follow-on Products

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

Bibiana Bielekova, Bonnie L. Goodwin, Nancy Richert et al. · Nature Medicine · 2000 · 826 citations

Life Sciences, Neurology, Neuroscience +17

Type II monocytes modulate T cell–mediated central nervous system autoimmune disease

Martin S. Weber, Thomas Prod’homme, Sawsan Youssef et al. · Nature Medicine · 2007 · 448 citations

Life Sciences, Immunology, Neuroscience +14

Design and Chemical Synthesis of a Homogeneous Polymer-Modified Erythropoiesis Protein

Gerd G. Kochendoerfer, Shiah-Yun Chen, Feng Mao et al. · Science · 2003 · 312 citations

Life Sciences, Biochemistry, Biotechnology +16

Rational design of a structural and functional nitric oxide reductase

Natasha Yeung, Ying-Wu Lin, Yi-Gui Gao et al. · Nature · 2009 · 240 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +12

Glatiramer acetate-specific T cells in the brain express T helper 2/3 cytokines and brain-derived neurotrophic factor <i>in situ</i>

Rina Aharoni, Başak Kayhan, Raya Eilam et al. · Proceedings of the National Academy of Sciences · 2003 · 232 citations · Full text

Life Sciences, Immunology, Neuroscience +17