Dose-Dependent Pharmacokinetics of Cyclosporin A in Rats: Events in Tissues

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

Clifford S. Patlak, Ronald G. Blasberg, Joseph D. Fenstermacher · Journal of Cerebral Blood Flow & Metabolism · 1983 · 3.6K citations · Full text

Pharmacy, Neuroscience, Pharmacokinetics +14

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

Human P-glycoprotein transports cyclosporin A and FK506.

Takashi Saeki, Kazumitsu Ueda, Yusuke Tanigawara et al. · Journal of Biological Chemistry · 1993 · 685 citations · Full text

Medicine, Biochemistry, Pharmacology +15

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Journal of Histochemistry & Cytochemistry · 1989 · 610 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Improved Dose Linearity of Cyclosporine Pharmacokinetics from a Microemulsion Formulation

Edgar A. Mueller, John M. Kovarik, Johannes B. van Bree et al. · Pharmaceutical Research · 1994 · 280 citations

Pharmacy, Pharmacokinetics, Pharmacology +16