Concepedia

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis

Neng‐Yu Lin, Christian Beyer, Andreas Gießl, Trayana Kireva, Carina Scholtysek, Stefan Uderhardt, Luis E. Muñoz, Clara Dees, Alfiya Distler, Stefan Wirtz,

Annals of the Rheumatic Diseases · 2012 · 259 citations · 30 references

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Abstract

These findings demonstrate that autophagy is activated in RA in a TNFα-dependent manner and regulates osteoclast differentiation and bone resorption. We thus provide evidence for a central role of autophagy in joint destruction in RA.

References

30

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