BMJ · 1980 · 132 citations · 5 references
MedicineInfectious DiseasesPharmacologyMedical MicrobiologyMolecular VirologyVirologyAntiviral AgentsAntiviral PharmacologyAntiviral PharmacotherapyAntiviral TherapyViral InfectionsViral PathologyAntiviral TherapeuticsCell Culture ConditionsHerpesvirus Antiviral TherapyNucleoside Analogue AntiviralsNucleoside Analogue TherapyNucleoside MetabolismTopical Antiviral TherapyTreatment Of Herpesvirus Infections
Oral (E)-5-(2-bromovinyl)-2'deoxyuridine in severe herpes zoster (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) is a nucleoside analogue that inhibits the replication of herpes simplex virus type 1 (HSV-1) in cell culture (primary rabbit kidney) at a concentration of 0 01 mg/l, but does not affect normal cell metabolism at concentrations up to 100 mg/I.' BVDU has also been found effective in the local and systemic treatment of HSV-1 skin lesions, and its associated mortality,
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PARENTERAL ACYCLOVIR THERAPY FOR HERPESVIRUS INFECTIONS IN MAN
Peter J. Selby, Beryl Jameson, J.G. Watson et al. · The Lancet · 1979 · 186 citations
Pharmacokinetics of <i>E</i> -5-(2-Bromovinyl)-2′-Deoxyuridine in Mice
Erik De Clercq, J Descamps, P. De Somer et al. · Antimicrobial Agents and Chemotherapy · 1979 · 26 citations · Full text