Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

G L Wang, Gregg L. Semenza · Proceedings of the National Academy of Sciences · 1993 · 1.5K citations · Full text

Reductive Stress, Transcriptional Regulation, Epo Gene +14

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

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Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

Bing‐Hua Jiang, Gregg L. Semenza, Christian Bauer et al. · American Journal of Physiology-Cell Physiology · 1996 · 1.2K citations · Full text

Redox Biology, Cellular Physiology, Oxidative Stress +19

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

Pradip K. Majumder, Phillip G. Febbo, Rachel Bikoff et al. · Nature Medicine · 2004 · 954 citations

Urology, Genitourinary Cancer, Hif-1-dependent Pathways +7

HIF‐1 is expressed in normoxic tissue and displays an organ‐specific regulation under systemic hypoxia

Deborah Stroka, Tobias Burkhardt, Isabelle Desbaillets et al. · The FASEB Journal · 2001 · 719 citations · Full text