The Journal of Immunology · 2008 · 132 citations · 15 references
Life SciencesImmunologyMicrobiologyHost-pathogen InteractionsInnate ImmunityMicrobial PathogenesisBacterial PathogenesisInnate Immune ActivationInnate Immune ReceptorsInnate Immune ResponseInnate Immune Signaling PathwaysToll-like ReceptorsBacterial Sensing ReceptorsHost Defense Against Bacterial InfectionInnate Immune EffectorsInnate Immune Recognition Of BacteriaInnate Immunity PathwaysInnate Sensing Of PathogensMyd88-dependent SignalingPattern Recognition Receptors In Bacterial Sensing
Several TLR ligands of bacterial origin induce innate immune responses. Although FimH, the adhesin portion of type 1 fimbria, plays an important role in the pathogenicity of some gram-negative bacteria, its ability to stimulate the innate immune system via TLR signaling remains unclear. In this study we report that FimH induces potent innate responses in a MyD88-dependent fashion. The FimH-induced innate activity was restricted to cells expressing TLR4. In addition, FimH was able to bind directly to TLR4. More importantly, cells unresponsive to LPS were responsive to FimH and the presence or absence of MD-2 and CD14 had no effect on FimH activity. Our data suggest that TLR4 is a functional receptor for the adhesin portion of bacterial type 1 fimbria.
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Essential role of MD-2 in LPS responsiveness and TLR4 distribution
Yoshinori Nagai, Sachiko Akashi, Masakazu Nagafuku et al. · Nature Immunology · 2002 · 1K citations
A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria
Dekai Zhang, Guolong Zhang, Matthew S. Hayden et al. · Science · 2004 · 1K citations
Life Sciences, Immunology, Urology +15