Inhibition of P-Glycoprotein by Newer Antidepressants

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995 · 1.1K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Richard B. Kim, Martin F. Fromm, Christoph Wandel et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17