Concepedia

Constitutive Androstane Receptor Activation Decreases Plasma Apolipoprotein B–Containing Lipoproteins and Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

Anne-Laure Sberna, Mahfoud Assem, Rui Xiao, Steve Ayers, Thomas Gautier, Boris Guiu, Valérie Deckert, Angélique Chevriaux, Jacques Grober, Naïg Le Guern,

Arteriosclerosis Thrombosis and Vascular Biology · 2011 · 36 citations · 23 references

DOIFull text

Open access

Abstract

CAR is a potential target in the prevention and treatment of hypercholesterolemia and atherosclerosis.

References

23

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Ben Langmead, Cole Trapnell, Mihai Pop et al. · Genome biology · 2009 · 22.5K citations · Full text

Crucial Step in Cholesterol Homeostasis

Tong Yang, Peter J. Espenshade, Michael E. Wright et al. · Cell · 2002 · 974 citations · Full text

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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

Ping Wei, Jun Zhang, Margarete Egan-Hafley et al. · Nature · 2000 · 648 citations

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CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice†

Martin Wagner, Emina Halilbasic, Hanns–Ulrich Marschall et al. · Hepatology · 2005 · 342 citations · Full text

Complementary Roles of Farnesoid X Receptor, Pregnane X Receptor, and Constitutive Androstane Receptor in Protection against Bile Acid Toxicity

Grace L. Guo, Gilles Lambert, Masahiko Negishi et al. · Journal of Biological Chemistry · 2003 · 304 citations · Full text