Concepedia

APOBEC3F Determinants of HIV-1 Vif Sensitivity

Allison M. Land, Nadine M. Shaban, Leah Evans, Judd F. Hultquist, John S. Albin, Reuben S. Harris

Journal of Virology · 2014 · 13 citations · 17 references

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Abstract

HIV-1 Vif counteracts restrictive APOBEC3 proteins by targeting them for proteasomal degradation. To determine the regions mediating sensitivity to Vif, we compared human APOBEC3F, which is HIV-1 Vif sensitive, with rhesus APOBEC3F, which is HIV-1 Vif resistant. Rhesus-human APOBEC3F chimeras and amino acid substitution mutants were tested for sensitivity to HIV-1 Vif. This approach identified the α3 and α4 helices of human APOBEC3F as important determinants of the interaction with HIV-1 Vif.

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