Concepedia

Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

Kengo Tomita, Toshiaki Teratani, Takahiro Suzuki, Motonori Shimizu, Hirokazu Sato, Kazuyuki Narimatsu, Yoshikiyo Okada, Chie Kurihara, Rie Irie, Hirokazu Yokoyama,

Hepatology · 2013 · 301 citations · 15 references

DOIFull text

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Abstract

These characteristic mechanisms of FC accumulation in HSCs are potential targets to treat liver fibrosis in liver diseases including NASH.

References

15

TLR4 enhances TGF-β signaling and hepatic fibrosis

Ekihiro Seki, Samuele De Minicis, Christoph H. Österreicher et al. · Nature Medicine · 2007 · 1.9K citations

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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

Jay D. Horton, Nila Shah, Janet A. Warrington et al. · Proceedings of the National Academy of Sciences · 2003 · 1.4K citations · Full text

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CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis

Isabelle Leclercq, Geoffrey C. Farrell, Jaqueline Field et al. · Journal of Clinical Investigation · 2000 · 770 citations · Full text

Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis

Francisca G. Caballero, Anna Colell, Albert Morales et al. · Cell Metabolism · 2006 · 594 citations · Full text

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Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

Arun Radhakrishnan, Joseph L. Goldstein, Jeffrey G. McDonald et al. · Cell Metabolism · 2008 · 544 citations · Full text

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