Concepedia

Treatment of colitis with a commensal gut bacterium engineered to secrete human tgf-β1 under the control of dietary xylan

Zaed Hamady, Nigel Scott, Mark D. Farrar, Meenu Wadhwa, Paula Dilger, Terence R. Whitehead, Robin Thorpe, Keith T. Holland, Peter J.A. Lodge, Simon R. Carding

Inflammatory Bowel Diseases · 2010 · 103 citations · 40 references

DOI

Abstract

This novel drug delivery system has potential for the targeted and controlled delivery of TGF-β(1) and other immunotherapeutic agents for the long-term management of various bowel disorders.

References

40

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor <i>Foxp3 </i>

WanJun Chen, Wenwen Jin, Neil J. Hardegen et al. · The Journal of Experimental Medicine · 2003 · 4.6K citations · Full text

T-regulatory Cell, Immune Regulation, Immunology +18

Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences

Edward V. Loftus · Gastroenterology · 2004 · 3.1K citations · Full text

Inflammation, Chronic Inflammatory Diseases, Environmental Influences +7

Treatment of Murine Colitis by <i>Lactococcus lactis</i> Secreting Interleukin-10

Lothar Steidler, Wolfgang Hans, L. Schotte et al. · Science · 2000 · 1.5K citations

Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring

Mamta Shah, David Foreman, Mark W. J. Ferguson · Journal of Cell Science · 1995 · 1.2K citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

Fiona Powrie, J A Carlino, Michael W. Leach et al. · The Journal of Experimental Medicine · 1996 · 894 citations · Full text

Cd4+ Cells, T-regulatory Cell, Immunology +19