Chemical Communications · 2006 · 231 citations · 79 references
Natural SciencesChemistryOrganic ChemistryCarbonyl ChemistryCross-coupling ReactionsHeterocycle SynthesisOrganic SynthesisRetrosynthetic AnalysisAsymmetric C-c Bond FormationCarbonyl Addition ReactionsCarbonyl Rearrangement ReactionsStereoselective C-h FunctionalizationStereoselective Cross-couplingStereoselective Reaction DesignStereoselective Synthesis
Despite the advances in stereoselective carbonyl allylation reactions, the creation of quaternary stereocenters in the addition of 3,3'-disubstituted allylmetals to aldehydes is still a challenging issue. This feature article describes the most powerful approaches that have been devised to address this problem.
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