Concepedia

Double strand DNA cleavage with a binuclear iron complex

Tieme A. van den Berg, Ben L. Feringa, Gérard Roelfes

Chemical Communications · 2006 · 54 citations · 18 references

DOI

Concepts

Abstract

Covalently linking two single strand DNA cleaving agents resulted in a new biomimetic binuclear iron complex capable of effecting oxidative double strand DNA cleavage.

References

18

Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II)

Robert Hertzberg, Peter B. Dervan · Journal of the American Chemical Society · 1982 · 407 citations

DNA double-strand breaks and alkali-labile bonds produced by bleomycin

Lawrence F. Povirk, Werner Wübker, Wolfgang Köhnlein et al. · Nucleic Acids Research · 1977 · 292 citations · Full text

, , +15

Nonheme Iron Centers in Oxygen Activation: Characterization of an Iron(<scp>III</scp>) Hydroperoxide Intermediate

Marcel Lubben, Auke Meetsma, Elizabeth Wilkinson et al. · Angewandte Chemie International Edition in English · 1995 · 260 citations

, , +19

End-On and Side-On Peroxo Derivatives of Non-Heme Iron Complexes with Pentadentate Ligands:  Models for Putative Intermediates in Biological Iron/Dioxygen Chemistry

Gérard Roelfes, Vladislav V. Vrajmasu, Kui Chen et al. · Inorganic Chemistry · 2003 · 251 citations

DNA Cleavage by Copper−ATCUN Complexes. Factors Influencing Cleavage Mechanism and Linearization of dsDNA

Yan Jin, J. A. Cowan · Journal of the American Chemical Society · 2005 · 249 citations

, , +16