Concepedia

GSK256066, an Exceptionally High-Affinity and Selective Inhibitor of Phosphodiesterase 4 Suitable for Administration by Inhalation: In Vitro, Kinetic, and In Vivo Characterization

Cathy Tralau-Stewart, Richard A. Williamson, Anthony T. Nials, Michele H. Gascoigne, John A. Dawson, Graham Hart, Anthony D.R. Angell, Yemisi Solanke, Fiona S. Lucas, Joanne Wiseman,

Journal of Pharmacology and Experimental Therapeutics · 2011 · 69 citations · 24 references

DOI

Concepts

References

24

Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

John F. Morrison · Biochimica et Biophysica Acta (BBA) - Enzymology · 1969 · 814 citations

, , +16

Tight-binding inhibitors—I

Sungman Cha · Biochemical Pharmacology · 1975 · 503 citations

Anti-Inflammatory and Immunomodulatory Potential of the Novel PDE4 Inhibitor Roflumilast in Vitro

Armin Hatzelmann, Christian Schudt · Journal of Pharmacology and Experimental Therapeutics · 2001 · 398 citations

, , +10

In Vivo Efficacy in Airway Disease Models of Roflumilast, a Novel Orally Active PDE4 Inhibitor

Daniela S. Bundschuh, Manfrid Eltze, Johannes Barsig et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 239 citations

, , +16

Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscle.

Theodore J. Torphy, Bradley J. Undem, L B Cieslinski et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 165 citations

, , +14