Concepedia

An Allosteric Coagonist Model for Propofol Effects on α1β2γ2L γ-Aminobutyric Acid Type A Receptors

Dirk Ruesch, Elena Neumann, Hinnerk Wulf, Stuart A. Forman

Anesthesiology · 2011 · 64 citations · 29 references

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Abstract

Our results support the hypothesis that propofol, like etomidate, acts at GABA(A) receptor sites mediating both GABA modulation and direct activation.

References

29

Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

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Identification of a GABA <sub>A</sub> Receptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog

Guodong Li, David C. Chiara, Gregory W. Sawyer et al. · Journal of Neuroscience · 2006 · 289 citations · Full text

Propofol and Other Intravenous Anesthetics Have Sites of Action on the γ-Aminobutyric Acid Type A Receptor Distinct from That for Isoflurane

Matthew D. Krasowski, Vladimir V. Koltchine, Caroline Rick et al. · Molecular Pharmacology · 1998 · 253 citations

General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility.

Matthew D. Krasowski, Andrew Jenkins, Pamela Flood et al. · PubMed · 2001 · 201 citations

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