Crystal Structure of a Spin‐Labeled, Channel‐Forming Alamethicin Analogue

Abstract

Crystal clear: A detailed conformational characterization of a synthetic analogue of the peptide antibiotic alamethicin (see structure; C gray, N blue, O red) has been achieved by X-ray diffraction. The high-resolution structure of this analogue, which incorporates a spin probe, paves the way for a better understanding of the mode of action of alamethicin.