Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs.

Abstract

The kinetics of entry and release of gentamicin was investigated in fluids and tissues of the inner ear of the rat, as well as in renal cortex, and in organs that do not share susceptibility to the toxic effects of aminoglycosides. Various modes of administration were used to achieve different patterns of drug plasma concentrations. Electrophysiological and histological examinations were per- formed to correlate pharmacokinetics and ototoxicity.