Concepedia

A Class of Allosteric Caspase Inhibitors Identified by High-Throughput Screening

Taya Feldman, Venkataraman Kabaleeswaran, Se Bok Jang, Christophe Antczak, Hakim Djaballah, Hao Wu, Xuejun Jiang

Molecular Cell · 2012 · 47 citations · 35 references

Open access

Concepts

PharmacyMedicinal ChemistryPharmacologyApoptosisDrug DesignDrug DiscoveryAllosteric Drug DesignAllosteric ModulationCaspase ActivationEnzyme InhibitionHigh-throughput ScreeningMolecular DockingAllosteric Drug DiscoveryAllosteric DrugsAllosteric InhibitionAllosteric Inhibition MechanismsAllosteric Ligand Discovery

References

35

[20] Processing of X-ray diffraction data collected in oscillation mode

Zbyszek Otwinowski, W. Minor · Methods in enzymology on CD-ROM/Methods in enzymology · 1997 · 33.6K citations

Natural Sciences, Materials Science, Physics +12

<i>Phaser</i>crystallographic software

Airlie J. McCoy, Ralf W. Grosse‐Kunstleve, Paul D. Adams et al. · Journal of Applied Crystallography · 2007 · 20.9K citations · Full text

Natural Sciences, Chemistry, Computational Chemistry +16

The Inflammasome

Fabio Martinon, Kimberly Burns, Jürg Tschopp · Molecular Cell · 2002 · 6K citations · Full text

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

Wolfgang Kabsch · Journal of Applied Crystallography · 1993 · 3.6K citations

Natural Sciences, Chemistry, Computational Geometry +16

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Tilman Oltersdorf, Steven W. Elmore, Alexander R. Shoemaker et al. · Nature · 2005 · 3.4K citations

Medicine, Molecular Biology, Oncology +14