Translating chitosan to clinical delivery of nucleic acid-based drugs

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Andrew Fire, Siqun Xu, Mary K. Montgomery et al. · Nature · 1998 · 15.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +8

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

Paul C. Zamecnik, Mary L. Stephenson · Proceedings of the National Academy of Sciences · 1978 · 1.8K citations · Full text

Life Sciences, Biology, Molecular Biology +15

Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency

Hai‐Quan Mao, Krishnendu Roy, Vu L. Troung-Le et al. · Journal of Controlled Release · 2001 · 1.2K citations

Pharmacy, Biotechnology, Molecular Pharmaceutics +16

Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy

Krishnendu Roy, Hai‐Quan Mao, Shau Ku Huang et al. · Nature Medicine · 1999 · 1.1K citations

Life Sciences, Biotechnology, Immunology +17

Modulation of surface charge, particle size and morphological properties of chitosan–TPP nanoparticles intended for gene delivery

Quan Gan, Tao Wang, Colette Cochrane et al. · Colloids and Surfaces B Biointerfaces · 2005 · 892 citations

Pharmacy, Biomedical Engineering, Biotechnology +17