Age-related increase in mitochondrial DNA damage and loss of DNA repair capacity in the neural retina

Gene regulation and DNA damage in the ageing human brain

Tao Lu, Ying Pan, Shyan‐Yuan Kao et al. · Nature · 2004 · 1.9K citations

Life Sciences, Genetics, Neuroscience +16

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

Arne Klungland, Ian Rosewell, Stephan Hollenbach et al. · Proceedings of the National Academy of Sciences · 1999 · 798 citations

Life Sciences, Genetics, Molecular Biology +17

Does oxidative damage to DNA increase with age?

Michelle L. Hamilton, Holly Van Remmen, Jessica A. Drake et al. · Proceedings of the National Academy of Sciences · 2001 · 761 citations · Full text

Life Sciences, Biochemistry, Genetics +15

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

Patrizia Mecocci, Usha MacGarvey, A. Kaufman et al. · Annals of Neurology · 1993 · 757 citations

Life Sciences, Genetics, Neuroscience +15

Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model.

Shinya Toyokuni, Tomoyuki Tanaka, Yuki Hattori et al. · PubMed · 1997 · 584 citations

Medicine, Cancer Biology, Oncology +8